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Why You Shouldn’t Mix Grapefruit and Statins

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Simvastatin side effects with grapefruit

The effect remains the same whether you cook the grapefruit or drink frozen or homogenized juice. Grapefruit juice can block the action of CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. Eating half a grapefruit is probably less risky because it contains a relatively small amount of juice but could still have an effect.

Grapefruit juice contains compounds called furanocoumarins that stop CYP3A from doing its job. Hazen takes a measured approach with his patients. So grapefruit juice may affect people differently oral minocycline when they take the same drug. By contrast, bitter oranges, pomelos, tangelos, and Seville oranges contain high levels of furanocoumarin and should also be avoided.

Just one grapefruit or one glass of grapefruit juice could be enough to cause an interaction with some medications. Page contents Further information Eating grapefruit or drinking grapefruit juice can affect some medicines.

Cardiologist Steven Nissen, MDpoints out that only certain statin medications interact negatively with grapefruit.

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Some drugs that treat high blood pressure, such as Procardia and Adalat CC both nifedipine. If your specific drug may metoclopramide action affected.

To be safe, check with your doctor if you take one of the two statins mentioned above.

If taken 12 hours apart, that drops to between 44 percent and 66 percent. As a result, more of the drug is absorbed, making it more powerful than it's meant to be — even toxic in some cases.

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All content is strictly informational and should not be considered medical advice. Luckily for grapefruit fans, there are cases in which moderate amount should be safe. Thanks for your feedback! Hazen takes a measured approach with his patients.

But if you can't switch, experts say it's probably okay to enjoy a small glass. These include many drugs used to treat blood vessel and heart conditions. If you have doubts or questions, talk to your doctor about the risks of mixing medications and grapefruit. Grapefruit juice can block the action of CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer with source website.

Certain anti-arrhythmia drugs, like amiodarone Certain anti-anxiety drugs, like buspirone Some antihistamines, like Allegra fexofenadine Certain corticosteroids, like budesonide Some hypertension medications, like nifedipine Some organ transplant rejection drugs, like cyclosporine Speak with your doctor or pharmacist if you regularly consume grapefruit to ensure that it doesn't interfere with your medications.

Some antihistamines, such as Allegra fexofenadine or apcalis jelly.

Advertising Policy There are several studies about grapefruit and statin interaction, and recent ones suggest that moderate grapefruit consumption can be compatible with taking lovastatin and other statin drugs. Food and Drug Administration and simvastatin 20 mg tablet tev.

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Simvastatin and grapefruit side effects

Simvastatin and grapefruit symptoms

Was this page helpful? Many drugs are broken down metabolized with the help of a vital enzyme called CYP3A4 in the small intestine. For example, you might need to stop taking Zocor or Lipitor, but you might be able to take a different statin.

How do statins work?

If I have a grapefruit or glass of grapefruit juice, is there a safe amount of time I should wait before taking my medication or vice versa? Advertising Policy Cleveland Clinic is a non-profit academic medical center. Advertising Policy There are several studies about grapefruit and statin interaction, and recent ones suggest that moderate grapefruit consumption can be compatible with taking lovastatin and other statin drugs - managing muscle pain related to cholesterol medication.

To be safe, restrict drinking and eating grapefruit if you take statins until you talk to your doctor about the risk. Grapefruit juice does not affect all the drugs in the categories above.

Furanocoumarins are found in other fruits and vegetables such as celery, parsnips, and pomegranatesbut are especially high in grapefruit and grapefruit juice. Severe side effects include muscle fiber breakdown and kidney failure.

Advertising on our site helps support our mission. Most evidence suggests that serious problems are more likely to occur if you consume large quantities over an extended period of time.

Statin Side Effects - Michael Rocco, MD

How this translates to the "safe" consumption of grapefruit remains unclear. Grapefruit juice and statins Q:

Most doctors will tell you that an occasional serving of juice or fruit will do you no harm. A number of studies have suggested that simvastatin side effects with grapefruit effects like these are uncommon and are mostly associated with a pre-existing kidney, liver, or amitriptyline and fluoxetine overdose condition.

Other studies have suggested that grapefruit in moderation showed no ill effects. As such, it is best to limit your consumption or to switch to "safe" citrus fruits, such as blood oranges, clementines, lemons, limes, mandarins, navel oranges, and tangerines.

Problems can occur for those who are sensitive to statin medications or those who have kidney disease or other illnesses. Some antihistamines, such as Allegra fexofenadine.

Most cases of a problem involved consuming large amounts. A number of studies have suggested that side effects like these are uncommon and are mostly associated with a pre-existing kidney, liver, or neurologic condition. Most doctors will tell you that an occasional serving of juice or fruit will do you no harm.

Grapefruit juice can cause problems with these enzymes and transporters, causing too much or too little drug in the body. Big effect. The outlook Although grapefruit interacts with over 85 medications, not all of the interactions cause serious side effects. The effect of grapefruit juice on some drugs may last longer than 24 hours and avoiding drinking any grapefruit juice is wise advice.

Some people have a lot of enzymes and others just a little. Grapefruit juice does not affect all the drugs in the categories above. Not all statins are affected equally by grapefruit juice, so grapefruit fans might want to switch to a statin that's less affected see the table below.

Other studies have suggested that grapefruit in moderation showed no ill effects. In most cases, it increases the level of the medicine in your blood.

What other fruits or juices may also affect your drug in a similar way to grapefruit juice. Seville oranges often used to make orange marmaladepomelos, and tangelos a cross between tangerines and grapefruit may have the same effect as grapefruit juice. What is most important is that you avoid the regular consumption or overconsumption of grapefruit in any form. What is known is that statin drug levels can increase by anywhere from 80 percent to percent if the medication is taken at the same time as grapefruit with singulair (montelukast).

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As a result, more of the drug is absorbed, making it more powerful than it's meant to be — even toxic in some cases. The effect of grapefruit juice on some drugs may last longer than 24 hours and avoiding drinking any grapefruit juice is wise advice. Grapefruit juice interacts with some calcium channel blockers and increases the level of the medicine in your blood.


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Do not stop taking your medication without advice.


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Safety and Considerations There is a popular assumption that grapefruit may be safe if eaten before or after a dose of Lipitor, Mevacor, or Zocor. If you consume grapefruit every now or then, it is unlikely to do any real harm. For example, you might need to stop taking Zocor or Lipitor, but you might be able to take a different statin.


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We do not endorse non-Cleveland Clinic products or services.


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Zocor simvastatin The interaction is caused by an organic compound in grapefruit known as furanocoumarin. Please try again. Looking to start a diet to better manage your cholesterol?


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